System/Hardware Tweaks

Change System Environment Variables
[HKEY_LOCAL_MACHINE\SYSTEM\CurrentControlSet\Control\Session Manager\Environment]
"TEMP"="N:\\Temp"
"TMP"="N:\\Temp"

Disable sticky keys (Popups up when pressing shift for some time, accessibility)
[HKEY_CURRENT_USER\Control Panel\Accessibility\StickyKeys]
"Flags"="506"

Disable the NTFS Last Access Time Stamp (speeds up viewing folders in ntfs)
[HKEY_LOCAL_MACHINE\SYSTEM\CurrentControlSet\Control\FileSystem]
"NtfsDisableLastAccessUpdate"=dword:00000001

Change the Number of Page Table Entries
[HKEY_LOCAL_MACHINE\SYSTEM\CurrentControlSet\Control\Session Manager\Memory Management]
"SystemPages"=dword:0000C350

Show Run in Separate Memory Space Option to run 16 bit programs in VDM
[HKEY_CURRENT_USER\Software\Microsoft\Windows\CurrentVersion\Policies\Explorer]
"MemCheckBoxInRunDlg"=dword:00000001

[HKEY_LOCAL_MACHINE\Software\Microsoft\Windows\CurrentVersion\Policies\Explorer]
"MemCheckBoxInRunDlg"=dword:00000001

Force Windows to Unload DLLs from Memory
[HKEY_LOCAL_MACHINE\SOFTWARE\Microsoft\Windows\CurrentVersion\Explorer\AlwaysUnloadDLL]
"Default"="1"

Improve Core System Performance **** WARNING : Requires atleast 512 MB RAM!
[HKEY_LOCAL_MACHINE\SYSTEM\CurrentControlSet\Control\Session Manager\Memory Management]
"DisablePagingExecutive"=dword:00000001

Increase IoPageLockLimit (disk cache)
Note- Use the following settings depending on your system RAM:
00020000 = 131072 KB (if RAM > 512 MB)
00010000 = 65536 KB (if RAM > 256 MB)
00008000 = 32768 KB (if RAM > 128 MB)
00004000 = 16384 KB (if RAM > 64 MB)
00002000 = 8192 KB (if RAM > 32 MB)
00001000 = 4096 KB (if RAM < 32 MB)
[HKEY_LOCAL_MACHINE\SYSTEM\CurrentControlSet\Control\Session Manager\Memory Management]
"IoPageLockLimit"=dword:00020000

Enable UDMA-66 Support (WARNING: Newer MOBOs only, intel chipsets)
Speeds up drives
[HKEY_LOCAL_MACHINE\System\CurrentControlSet\Control\Class\{4D36E96A-E325-11CE-BFC1-08002BE10318}\0000]
"EnableUDMA66"=dword:00000001

Optimize L2 Cache Detection (Manual)
Note: Change the setting depending on the L2 Cache of your CPU.
If you dont know the L2 cache of your CPU, use a freeware program like CPU-Z
http://www.cpuid.com/cpuz.php

8192 KB = 00002000
4096 KB = 00001000
2048 KB = 00000800
1024 KB = 00000400
512 KB = 00000200
256 KB = 00000100

[HKEY_LOCAL_MACHINE\SYSTEM\CurrentControlSet\Control\Session Manager\Memory Management]
"SecondLevelDataCache"=dword:00000800

Prioritize CMOS RealTime Clock Using IRQ8
[HKEY_LOCAL_MACHINE\SYSTEM\CurrentControlSet\Control\PriorityControl]
"Win32PrioritySeparation"=dword:00000026
"IRQ8Priority"=dword:00000001

nVidia OverClock/Tweak mode enable (Note: Use only if you have an nVidia Card!
[HKEY_LOCAL_MACHINE\SOFTWARE\NVIDIA Corporation\Global\NVTweak]
"CoolBits"=dword:00000003